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【產品介紹】The 32kDa dopamine a n d cyclic
adenosine 3'',5''-monophosphate-regulated
phosphoprotein (DARPP-32) can either function as
a serine/threonine kinase o r as a serine/
threonine phosphatase depending upon which particular
amino acid residue is phosph o r ylated (1). When phosph
o r ylated by protein kinase A (PKA) at threonine
34, DARPP-32 becomes a potent inhibit o r of
protein phosphatase-1 (2-3). Alternatively, when phosph
o r ylated at threonine 75 by cyclin-dependent
kinase 5(Cdk5), DARPP-32 is converted into an inhibit o r
of PKA (1). DARPP-32 a n d t r u n c a t e d DARPP
(t-DARPP) are overexpressed in gastric cancers (4).
WB: 1:5,000-20,0000
IHC: 1:250-500
ICC: 1:50-100
IP: 1:50
A. Western blot analysis on human brain lysate
using anti-DARP-32 (C-term) RabMAb (cat. # 1711-1),
dilution 1:20,000. B. Immunohistochemical analysis of paraffin-embedded
human gastric adenocarcinoma using anti-DARPP-32
(C-term) RabMAb (cat. # 1711-1). |
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