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| 生化科研試劑 >> 抗體產品 >> 一抗 |
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JAK3
JAK3 |
| 別????名： |
Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| 貨號 |
品名 |
規格 |
包裝 |
單價 |
貨期 |
庫存 |
| 1227179011 |
JAK3 |
|
100ul |
詢價 |
現貨 |
3天 |
| 提示信息：偏遠地區如新疆西藏寧夏甘肅等地可能無法運送液體，下單前請聯系客服。 |
| 性 狀： |
【產品類型】Rabbit Polyclonal IgG Affinity Purified
【反應特異性】Human , Rat
【克隆 ID】Polyclonal
【用途】WB
【產品性狀】
【陽性對照】
【產品濃度】
【細胞定位】
【抗原分子量】115 kDa |
| 質量標準： |
【產品介紹】Jak3 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to
transduce extracellular signals from cytokines
a n d interferons. Jaks associate with cytokine recept
o r s; upon lig a n d binding, Jaks phosph o r ylate
the recept o r . The phosph o r ylated recept o r s
are bound by SH2-containing proteins, one class of which
is the signal transducers a n d activat o r s
of transcription (STATs). Activated STATs translocate to
the nucleus to mediate gene transcription (1, 2). Jak3
is activated after binding to the gamma chain of
Interleukin recept o r s, specifically IL-2, IL-4,
IL-7, IL-9, a n d IL-15 recept o r s. Jak3 has
been implicated in mast cell-mediated
immediate hypersensitivity reactions, autoimmune dis
o r ders, a n d acute lymphoblastic leukemia. Jak3 inhibit
o r has shown clinical potential as a new class
of immunomodulat o r y agents with anti-leukemic
a n d immunosuppressive properties (3).WB: 1:2000 A. Western blot using anti-Jak3 Rabbit Polyclonal
(cat. # 1752-1) on TF-1 cell lysate at 1:2000 dilution. |
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