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【產品介紹】Kininogen-1 exists as two different
proteins: high molecular weight kininogen (HMWK) and
low molecular weight kininogen (LMWK). HMWK is essential
for blood coagulation and assembly of the kallikrein-
kinin system. Also, bradykinin, a peptide causing
numerous physiological effects, is released from HMWK.
In contrast to HMWK, LMWK is not involved in
blood coagulation (1).Recommended Applications
WB, IHC, IP
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:100 - 250
IP: 1:10 - 100
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) human plasma, (B)
human platelet, and (C) ovarian cancer lysates
using anti-Kininogen-1 RabMAb (cat. #5183-1). Immunohistochemical analysis of paraffin-embedded
human kidney tissue using anti-Kininogen-1 RabMAb
(cat. #5183-1). Immunohistochemical analysis of paraffin-embedded
human ovarian adenocarcinoma tissue using
anti-Kininogen-1 RabMAb (cat. #5183-1). Specificity
A synthetic peptide corresponding to residues in
human Kininogen-1 was used as an immunogen. This
antibody detects three isoforms of Kininogen-1: full
length (120 kDa), light chain (56 kDa), and cleavage
form (45 kDa). |
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