Recombinant Mouse Stromal-Cell Derived Factor-1 alpha/CXCL12 是 CXC 趨化因子家族成員,能夠結合 CXCR4、CXCR7,與腫瘤的增殖、存活、血管生成、轉移及免疫抑制有關。 Synonyms rMuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF ; 重組小鼠基質細胞衍生因子-1α/CXCL12 Species MouseSource E. coli Accession P40224 Gene ID 20315 Molecular Weight Approximately 8.0 kDa AA Sequence KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Biological Activity Full biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Mouse Stromal-Cell Derived Factor-1 alpha/CXCL12 (rMuSDF-1α/CXCL12) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Mouse Stromal-Cell Derived Factor-1 alpha/CXCL12 (rMuSDF-1α/CXCL12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background CXCL12 belongs to the CXC chemokine family, and is expressed in two isoforms, SDF-1α and SDF-1β, binds to CXCR4 and CXCR7. CXCL12/CXCR4 signal is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression[1]. |